High Wycombe skipper Dan Marles hit an unbeaten 154 as his side recorded their first win of the season.
Marles was joined in the run spree by Conrad Louth, who hit a run-a-ball century, as Wycombe posted 364 for 4 from their 50 overs.
In reply, Slough were dismissed for 111 all out with Cameron Parsons, four for 11, the pick of the bowlers.
Current Champions Henley recorded a nine-wicket win at Tring Park after winning the toss and electing to bowl.
Andy Rishton’s three for 32 helping bowl out the home side for 109.
Henley lost just one wicket reaching their target with Matthew Rowe making an unbeaten half century to add to his 53 last week.
Banbury returned from Horspath with a five-wicket win to make it back-to-back wins.
Shahid Yousaf top-scored with 55 while Shazad Rana batted excellently again with an unbeaten 34 to take Banbury home.
Earlier in the day, Horspath posted 188 for 7 with Tom Coleman making 49. Joe Thomas and John West taking a brace of wickets each for the visitors.
Newly promoted Datchet won again as they defeated Aston Rowant.
Datchet made 240 for 8 with Joe Barrett’s 75 and and an undefeated 62 from Vishal Aeri in form.
Aston Rowant’s run chase fell 11 runs short with Olly Birts four for 46 and Bobby Sher’s three for 43 doing the damage for Datchet.
Finchampstead defeated Buckingham by 148 runs – see report below.
MATCH DAY 2 TABLE pic.twitter.com/d14yO1FJem
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